I was just up in Ames visiting Reiman Gardens last week. I'd suggest Vesuvius Wood-Fired Pizza for lunch. They bill themselves as a Neapolitan-style pizza place, and while you can argue about that, they do serve simple, very tasty pizza.
Right in Ames is Battle's Bar-B-Q, which serves excellent Texas-style barbecue, and makes their own sides, a real surprise in Iowa.
Vesuvius Wood-fired Pizza
1620 S. Kellogg
Ames, IA 50010
http://www.vesuvius-wfp.com/Vesuvius_Wo ... omise.htmlBattle's Bar-B-Q
218 Welch Ave
Ames, IA 50014
Des Moines has more options. If I were there on a Saturday morning, I'd have breakfast at the downtown Des Moines Farmers Market. They open pretty early, so you could stop there on your way up to orientation, if you're all early risers.