Though only 4-inches difference the WSM 22.5 is substantially larger than the 18.5, deceptively so.
New model WSM 22.5, old model WSM 18.5
The 22.5 offers typical WSM rock solid temperature control and capacity, four packer cut briskets, eight pork shoulders no problem on the 22.5. Negatives are slightly shorter burn time with full lump load, increased fuel consumption and a tendency to run hot. The size difference makes the 22.5 generally more cumbersome, plus with 3-gallons of water (24-lbs) and 60-70 pounds of meat it can get pretty heavy.
My 22.5 has been loaned out quite a bit, and everyone who's used it has nothing but positive comments, myself included, but if you don't need the increased capacity the 18.5 is the way to go.
Far as
Low & Slow and the 22.5, it will run slightly hotter, especially when new, go through lump charcoal faster, but there are no changes to be made in the 5 lessons for the larger WSM.
Enjoy,
Gary