I'd probably roast at 350° - but you could go to 375° or so if you want the outside better done (increased Maillard reaction) and the inside a little rarer.
Since it's such a tender cut, you could grill it too. Have you thought of slicing it thin, pounding it out, and making a venison scallopini? I would definitely second the suggestion of a port reduction, maybe with a few finely chopped shallots to go with it.
The chuck roast could make a great braise.