The little I do know about that area I will share with you. My parents live outside of Buffalo now, and when I visit I usually stay home with them, which is why my knowledge is limited. But, there are some things worth looking into.
-The Frank Lloyd Wright houses - I think there are 2. One may still be under renovation, but they often do tours even while this is going on. These are in the nice suburbs of Buffalo, which have some beautiful old houses. Unfortunately the downtown is quite empty(even though the architecture is great) because the school system there is awful, the taxes are high, and no one wants to stay.
-The Albright-Knox Museum. Quite good and doable in a few hours.
-Anchor Bar: I have heard their wings have become quite soggy, but I haven't been there myself.
-If you go to Niagara, go to the CANADIAN side. It is much prettier and cleaner. A nice area to walk around is Niagara on the Lake. Also near there, if you have kids, or if you would just enjoy it, is a Butterfly Greenhouse, filled with spectacular plants and beautiful butterflies. Again the houses around this area are very nice.
-I don't have more tips about where to eat unfortunately, but one place we ate (which is in Amherst) was called Siena, and it had good, rustic, provence-style food. But that's if you're near there, and things are quite spread out in that area.
-Good luck!
"Food is Love"
Jasper White