37 subjects took part, all confirmed not to have celiac disease but whose gastrointestinal symptoms improved on a gluten-free diet, thus fulfilling the diagnostic criteria for non-celiac gluten sensitivity.** They were first fed a diet low in FODMAPs for two weeks, then were given one of three diets for a week with either 16 grams per day of added gluten (high-gluten), 2 grams of gluten and 14 grams of whey protein isolate (low-gluten), or 16 grams of whey protein isolate (placebo). Each subject shuffled through every single diet so that they could serve as their own controls, and none ever knew what specific diet he or she was eating. After the main experiment, a second was conducted to ensure that the whey protein placebo was suitable. In this one, 22 of the original subjects shuffled through three different diets -- 16 grams of added gluten, 16 grams of added whey protein isolate, or the baseline diet -- for three days each.
Analyzing the data, Gibson found that each treatment diet, whether it included gluten or not, prompted subjects to report a worsening of gastrointestinal symptoms to similar degrees. Reported pain, bloating, nausea, and gas all increased over the baseline low-FODMAP diet. Even in the second experiment, when the placebo diet was identical to the baseline diet, subjects reported a worsening of symptoms! The data clearly indicated that a nocebo effect, the same reaction that prompts some people to get sick from wind turbines and wireless internet, was at work here. Patients reported gastrointestinal distress without any apparent physical cause. Gluten wasn't the culprit; the cause was likely psychological. Participants expected the diets to make them sick, and so they did. The finding led Gibson to the opposite conclusion of his 2011 research:
“In contrast to our first study… we could find absolutely no specific response to gluten."
Instead, as RCS reported last week, FODMAPS are a far more likely cause of the gastrointestinal problems attributed to gluten intolerance. Jessica Biesiekierski, a gastroenterologist formerly at Monash University and now based out of the Translational Research Center for Gastrointestinal Disorders at the University of Leuven in Belgium,* and lead author of the study alongside Gibson, noted that when participants consumed the baseline low-FODMAP diet, almost all reported that their symptoms improved!
"Reduction of FODMAPs in their diets uniformly reduced gastrointestinal symptoms and fatigue in the run-in period, after which they were minimally symptomatic."
Coincidentally, some of the largest dietary sources of FODMAPs -- specifically bread products -- are removed when adopting a gluten-free diet, which could explain why the millions of people worldwide who swear by gluten-free diets feel better after going gluten-free.
mamagotcha wrote:Well, this study didn't look at the things that many gluten-intolerant folks deal with, like brain fog and joint pain. I know that gluten will cause me to be very sleepy about an hour after I eat it, and I will have an arthritis flare after about six hours that usually lasts a day or so. The way this study has been posted around on social media, it's clear that people think this is all in our heads... but this study didn't even look at those symptoms. Grr!
laikom wrote:So, you are saying you have tried an otherwise FODMAPS free diet then introduced pure gluten, and still had all of these other symptoms?
riddlemay wrote:laikom wrote:So, you are saying you have tried an otherwise FODMAPS free diet then introduced pure gluten, and still had all of these other symptoms?
Honestly, I don't think we know enough yet about the mind-body connection as it affects all kinds of things. Even if certain symptoms are psychosomatic (and I'm not saying that in any particular case they are), they are nonetheless real. "Psychosomatic" has become a disrespected word, but it oughtn't to be. In the hypothetical case that my experience is that I get asthmatic symptoms every time I have, let's say, blueberries in my food, then a restaurant ought to do what it can to make sure I don't get blueberries in my food--no matter whether histamines create the reaction, or the mind creates the histamines that create the reaction.
Mind you, I'm not saying a restaurant has to throw out all its cooking apparatus for the sake of one customer's needs. I'm saying that the restaurant should do what it can. And if a restaurant cannot accommodate, it should inform the customer of its limits so the customer has the information he needs to make a safe food choice. That's just civility.
laikom wrote:I don't think anyone here, nor the studies attributed any symptoms to a psychosomatic effect.
Analyzing the data, Gibson found that each treatment diet, whether it included gluten or not, prompted subjects to report a worsening of gastrointestinal symptoms to similar degrees. Reported pain, bloating, nausea, and gas all increased over the baseline low-FODMAP diet. Even in the second experiment, when the placebo diet was identical to the baseline diet, subjects reported a worsening of symptoms! The data clearly indicated that a nocebo effect, the same reaction that prompts some people to get sick from wind turbines and wireless internet, was at work here. Patients reported gastrointestinal distress without any apparent physical cause. Gluten wasn't the culprit; the cause was likely psychological. Participants expected the diets to make them sick, and so they did.
mgmcewen wrote:Most people can adapt to some level of consumption, particularly of lower lactose fermented products.
boudreaulicious wrote:Nice work NeroW.
I think the most delicious part of any restaurant meal is the hospitality. Great service elevates good food. Poor service can make it taste like shit. Unfortunately, there are restaurant staff who forget this and guests who don't have the sense to properly appreciate those who do it right.
Gluten free, deathly allergic, I don't like it--does it really matter? It shouldn't. The guest should ask, politely. The more restrictive the diet, the farther in advance and the higher up the chain they should ask. The restaurant staff--server, cooks, chef--should answer honestly, and with as much accommodation as is reasonable. This may vary a lot, depending on the restaurant. But I see no compelling reason why the asking and the responding should be anything other than a civil, easy exchange, as NeroW so professionally demonstrates.
riddlemay wrote:boudreaulicious wrote:Nice work NeroW.
I think the most delicious part of any restaurant meal is the hospitality. Great service elevates good food. Poor service can make it taste like shit. Unfortunately, there are restaurant staff who forget this and guests who don't have the sense to properly appreciate those who do it right.
Gluten free, deathly allergic, I don't like it--does it really matter? It shouldn't. The guest should ask, politely. The more restrictive the diet, the farther in advance and the higher up the chain they should ask. The restaurant staff--server, cooks, chef--should answer honestly, and with as much accommodation as is reasonable. This may vary a lot, depending on the restaurant. But I see no compelling reason why the asking and the responding should be anything other than a civil, easy exchange, as NeroW so professionally demonstrates.
Agree completely.
JoelF wrote:Reading up on the FODMAP stuff (through Wikipedia), I have to wonder.
The major groups of FODMAPs are Fructans, Galactans and Polyols.
Galactans are mainly found in beans -- a staple in gluten-free diets.
Polyols are in a number of fruits, cauliflower, and mushrooms.
Fructans would seem like the culprit for the something-other-than-gluten-sensitive... but one of the highest concentrations of Fructans is in Barley (although it does say "kernels, very young"), another staple of the gluten-free diet.
Garlic, Artichokes and Jerusalem Artichokes (aka fartichokes) are also rather high in Fructans - they might be a good thing to use as a qualifying test in your diet.